Simultaneous determination by gas chromatography of the major metabolites in urine of toluene, xylenes and styrene.
نویسندگان
چکیده
A gas chromatographic method has been developed to determine the following metabolites in urine simultaneously if necessary: hippuric acid from toluene or styrene; 3- and 4-methyl hippuric acids from xylenes; phenylglyoxylic acid and mandelic acid from styrene. Heptadecanoic acid is added to the urine as an internal standard and after ethyl acetate extraction from acidic solution, the trimethylsilyl (TMS) derivatives of the metabolites are formed and simultaneously analysed by gas chromatography on 3% OV-1 on 80/100 gas chrom Q (flame ionisation detector).
منابع مشابه
Simultaneous determination of aromatic acid metabolites of styrene and styrene-oxide in rat urine by gas chromatography-flame ionization detection.
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ورودعنوان ژورنال:
- British journal of industrial medicine
دوره 35 1 شماره
صفحات -
تاریخ انتشار 1978